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Depression and ED: Side Effect of Anti-depressants in Men’s Sexual Health

October 29, 2024

Clinical depression and erectile dysfunction can have a devastating effect in man’s life. Also, lowered libido works to disrupt men’s ability to maintain a satisfying sex life. Several anti-depressant medications are proven effective as treatment for depression. Furthermore, research reveals that side effects of anti-depressants can cause erectile dysfunction and impotence in men. A recent study by the University of Virginia’s Department of Psychiatric Medicine supports how erectile dysfunction arises among 37% of men under anti-depressant medication.

Why do some antidepressants can lower libido?

Selective serotonin reuptake inhibitor (SSRI) is a first class psychotropic drug to address depression that works by inhibiting dopamine and norepinephrine reuptake. These neurotransmitters are responsible for sexual stimulation.

SSRIs are the most prescribed antidepressant medication than TCA and MAO inhibitors.  Although, TCA and MAO inhibitors are also link to poor sex drive and loss of sexual stimulation. Evidence relating anti-depressant medications to sexual dysfunction is inconclusive. Serotonin also works to decrease sexual arousal and hampers nitric oxide release in the bloodstream.  Nitric oxide relaxes penile muscles, allowing adequate blood flow to the penis. Hence, a drop in nitric oxide in the bloodstream can result to sexual dysfunction.

Finding the Right ED treatment

There are several ED treatment options available in the market. Some erectile dysfunction treatments are helpful along with other anti-depressant medications. Intracavernous pharmacotherapy, sexual and emotional counseling, as well as hormonal replacements are beneficial for men with depression and erectile dysfunction.

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