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Tadexetine™: Innovative Combination Pill for PE
Premature Ejaculation Associated With ED
It appears that most men, especially from middle-aged and older, who experience premature ejaculation for the first time later in life, may in fact have underlying erectile dysfunction. The symptoms of ED can range from mild to severe. Once the diagnosis is made, you may consider treating them both with a new compounded medication called Vardexetine™ or Tadexetine™.
Vardexetine™ is a compounded medication of vardenafil (Levitra) and paroxetine.
Tadexetine™ is a compounded medication of tadalafil (Cialis) and paroxetine.
Ingredients:
Vardenafil (Levitra or Staxyn) and Tadalafil (Cialis) are common drugs used for erectile dysfunction. They both belong to the same family of drugs called PDE5 inhibitors. PDE5 inhibitors increase nitric oxide (NO) levels which lead to increased blood flow to the penis during sexual arousal, causing a harder erection.
Common side-effects of PDE5 inhibitors may include:
- For vardenafil: headache, facial flushing, dizziness, visual disturbances.
- For tadalafil: headache, back pain, indigestion, muscle aches
Paroxetine is a type of antidepressant known as an SSRI (selective serotonin reuptake inhibitor). It’s often used to treat depression and also sometimes obsessive compulsive disorder (OCD), panic attacks, anxiety or post-traumatic stress disorder (PTSD). Paroxetine and other SSRIs are prescribed as off-label uses to treat Premature Ejaculation. It works by increasing the amount of 5-hydroxytryptamine (5-HT) in postsynaptic membrane receptors and thus delay ejaculation.
Common side-effects of paroxetine may include: nausea, drowsiness, dizziness, trouble sleeping, loss of appetite, weakness, dry mouth, sweating, blurred vision, and yawning. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
How does it work?
Each ingredient exerts its effects independently. Vardenafil or Tadalafil result in harder erections and paroxetine delays the ejaculation.
Men often experience much stronger erections than they have had in years, even though ED is not their primary concern. On average, it may take between 10-20 minutes to reach orgasm.
How effective is it?
Very effective. The ejaculation is delayed in over 90% of men.
If it takes too long, a revised prescription may be necessary.
How do I take it?
For best results, take one pill orally 3-4 hours before the anticipated sexual activity and use it as needed.
Associated Poor Sexual Arousal and Satisfaction
Men who experience premature ejaculation associated with ED often complain of another symptom: poor sexual arousal and reduced sexual satisfaction. One may consider adding a short-term use of Bremetide™.
Bremetide™ (Bremelanotide) is a subcutaneous injection which results in increased erections in men, and increased sexual desires and satisfaction in both men and women. In fact, this medication was FDA-approved in 2019 under the trade name “Vyleesi” to treat hypoactive sexual desire disorder in premenopausal women. But it works equally effective in men as well.
Vyleesi is a manufactured drug and the cost is prohibitive, however:
Bremetide™ is compounded by an FDA sourced facility and is much more affordably priced. One can start and stop using it at any time. Men often find that Bremetide™ adds much more to the quality of their sex life and continue to use it as desired.
References:
“Discovery that a melanocortin regulates sexual functions in male and female humans”. Peptides. 26 (10):1687-9
Hadley ME. (October 2005). https://pubmed.ncbi.nlm.nih.gov/15996790/
“Melanocortin receptors, melanotropic peptides and penile erection”. Current Topics in Medicinal Chemistry. 7 (11): 1098-1106.
King SH, Mayorov AV, Balse-Srinivasan P, Hruby VJ, Vanderah TW, Wessells H. (2007) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694735/
“Melanocortins in the treatment of male and female sexual dysfunction”.
Shadiack, Annette & D Sharma, Shubh & C Earle, Dennis & Spana, Carl & J Hallam, Trevor. (2007). https://pubmed.ncbi.nlm.nih.gov/17584134/
This information is provided for general reading only. It is not intended to diagnose or treat any medical condition for any patient.
Please consult your treating physician for any concerns you may have.
