Call US : 800-337-7555

Boston Medical Group

boston medical group

Poll: How much sex are people really having now?

by

Half a year ago, when the COVID-19 pandemic was rampant, we asked, “how often are you having sex?”

The COVID-19 Pandemic has made it increasingly difficult to maintain healthy relationships with our significant others. You may have had to social distance for longer durations, or maybe you had actually gotten sick of being cooped up together without a break. Interestingly, the majority of people answered that they had sex weekly; however, the second highest vote was rarely or never.

While we’re now seeing some hope for the pandemic from more vaccinations, AND it’s finally summer – has there been changes to your sex life? Find out what other couples are experiencing too after answering our short poll! 

Exosomes. Extraordinary Extracellular Vesicles

by

Let it never be said that nature has run out of surprises. Or that science has run out of discoveries. Exosomes are extracellular vesicles (EVs) first described as such 30 years ago and since implicated in cells, cell communication and the transmission of disease states. Fundamental questions about their biology remain unanswered. Here is the current definition and some of the outstanding issues in exosome biology –

 

The exosome is composed of all of the exons within the genome, the sequences which, when transcribed, remain within the mature RNA after introns are removed by RNA splicing. This includes untranslated regions of mRNA, and coding sequence (or CDS). Exome sequencing has proven to be an efficient method to determine the genetic basis of more than two dozen Mendelian or single gene disorders.

 

Exosomes and the Future of Erectile Dysfunction Treatment.

 

Erectile dysfunction, or ED, affects nearly half of men between the ages of 40 and 70 to some extent. Vascular diseases interrelated with aging, hyperlipidemia, smoking, diabetes as well as hypertension, are often linked to erectile dysfunction. Furthermore, injury to cavernous nerves in the penile region “comprises an appreciable number of ED cases.” Other causes of erectile dysfunction include, but are not limited to endocrine disorders, as well as fibrosis of the penile tissue and corporal smooth muscle.  Overall, both vasculogenic and neurogenic erectile dysfunctions are linked to the loss of normal cellular function or cell death (apoptosis).

Oral medications such as phosphodiesterase-5 inhibitors (PDE5is), have clear benefits. Most recently, however, scientists and physicians have been focusing on new, next-generation, novel therapy options as a way to restore natural sexual function. One such treatment option includes Stem-Cell-based Bioactive Factor Therapy.

 

Stem-cell-based therapies focus on the management of erectile dysfunction “through the protection of the threatened host cells via immunomodulatory effects, and the provision of trophic factors or gene delivery.” In recent years, a number of research studies are supporting the concept that stem cell-based bio-active therapy is potentially the next generation therapeutic approach for erectile dysfunction.

 

 

https://vimeo.com/495598379

 

 

What are Mesenchymal Stem Cells?

 

Stem cells differentiate into smooth muscle cells, neurons, endothelial cells and other types of varying cells. Stem cells by definition have the capability of self-renewal, meaning that they can make copies of themselves for an indefinite period, and differentiate into a variety of phenotypes. Stem cells represent great promise for regenerative medicine.” Stem cells can be categorized as either embryonic stem cells (ESCs) or adult stem cells (ASCs). Mesenchymal stem cells (MSCs) are adult stem cells which can be isolated from human and animal sources. The word “Stem Cells” more correctly known as “Mesenchymal Stem Cells” (MSCs) were termed MSCs secondary to their innate ability to duplicate while maintaining the attribute of multi-potential lineage

 

What are Bioactive Factors and EVs?

 

MSCs are able to secrete “Bioactive Factors”, such as exosomes and other extracellular vesicles (EVs), which aid in modulating the immune system, improve the standard rate of healing injured tissues and reduce inflammation. Stem Cell Bioactive Factors consist of nanoparticles which are released from the membranes of Mesenchymal Stem Cells (MSCs). These nanoparticles contain over “200 Growth factors, Cytokines and Nucleic Acids which support healthy cell-to-cell communication and are responsible for the therapeutic effects observed in regenerative medicine,” as well as perform a critical role in important processes such as immune responses, homeostasis maintenance, and more.

 

Microvesicles, an important EV, may “change functional target cells by delivering intracellular proteins.” For example, MVs released from endothelial cells can promote the regeneration through transfer of growth factors and their activators. MSC-derived EVs (MSC-EVs)-based stem cell therapies are easier to manage and safer “due to their inability to directly form tumors.”

 

 

Mesenchymal Stem Cell’s Bioactive Factors

 

Bioactive Factors demonstrate numerous advantages when compared to Mesenchymal Stem Cells:

  • Bioactive Factors do not contain DNA as they have no cells therefore there is no risk of a malignant transformation.
  • Bioactive Factors contain nanoparticles, which can travel systemically without the risks of clumping.
  • Bioactive Factors have the ability to cross the Blood Brain Barrier (BBB) and are able to exert their neurotrophic effects.
  • MSCs can be perceived as “foreign” by our own immune system (both innate and adaptive); however, Bioactive Factors are able to evade immune response.

Essentially Bioactive Factors exert far more therapeutic effects than Mesenchymal Stem Cells could.

 

Therapeutic Effects of Stem Cell Bioactive Factors

 

Growth factors, cytokines, and nucleic acids within stem cell bioactive factors are catalysts for regeneration as they contribute to tissue and organ repair, alter inflammation, aid in neural communication, improve mitochondrial viability and participate in the alteration of aging cells. Overall, bioactive factors derived from stem cells aid the body in repairing damaged tissues and injuries.

 

Stem cell bioactive factors have been utilized by medical professionals for a number or varying aspects including, but not limited to, soft tissue repair, and restoring sexual wellness. In regards to men’s sexual health, Exosomes Therapy rejuvenates, repairs, and regenerates damaged penile tissues, aiding in the restoration of erectile function which may contribute to eliminating the need for long term reliance on drugs.

 

Some Examples of Bioactive (Growth) Factors

 

  • VEGF (Vascular Endothelial Growth Factors): Aids in the creation of new blood vessels, and in the generation of muscles through bypassing blocked vessels.
  • PDGF-BB (Platelet Derived Growth Factor Sub Unit B): Stimulates the healing of soft as well as hard tissues.
  • TGF B3 (Transforming Growth Factor B3): Aids in the conversion of inflammatory T cells into anti-inflammatory Regulatory T cells.
  • GDF 15 (Growth Differentiation 15): Regulates inflammation and aids in cell repair as well as growth.

 

How Boston Medical Group Sources Bioactive Factors (Exosomes)

 

Boston Medical Group utilizes Exosomes produced from an FDA-registered Tissue Bank which follows strict GMP guidelines and implements as well as maintains FDA regulations. The Tissue Bank sources from the highest quality donors and harvests from the healthiest part of the placenta in order to produce viable MSCs from which secreted Exosomes are collected at the highest point potency. Upon the completion of manufacturing, each batch is sent for third party testing regarding microbiology and other safety protocols.

 

Clinical Trials Regarding Stem Cell Therapies and Erectile Dysfunction

 

Exosomes Therapy can utilize varying types of stem cells including MSCs. Exosomes may also treat erectile dysfunction by supporting penile tissue through paracrine or hormone effects such as the “release of repair cytokines triggering endogenous mechanisms of regeneration separate from the transdifferentiating of stem cells into different cell types.” Furthermore, MSCs do not necessarily need to be engrafted within tissue to create a functional and structural response to the therapy administered.

 

Phase one studies in humans have shown “results in terms of tolerability, safety, and efficacy of use of stem cell transplant for the treatment of erectile dysfunction.” Recent studies have also suggested that the combination shockwave therapy and stem-cell bioactive factors or Exosomes Therapy may decrease cell destruction within the penile corpora region as well as promote the growth of new blood vessels.

 

A literature review from ScienceDirect regarding the efficacy of stem-cell bioactive factors therapy revealed that five previously completed human clinical trials did show promise for the therapy as “being a restorative treatment option for erectile dysfunction,” the five studies included in the literature review utilized different types of stem cells, including various mesenchymal stem cells (MSCs). A total of 61 patients were included in the five studies, with mean ages of men being between 50 and 70 years. The literature review found that the majority of the five studies suggested improvement in erectile function and vascular flow in the penile region due to stem cell therapy without the report of serious adverse events occurring during the follow-up period.

 

Exosomes Therapy may be a paradigm shift in the growing number of treatment options available for erectile dysfunction. Exosomes Therapy has been recognized for its therapeutic properties in regards to aiding in treatment for various conditions including erectile dysfunction. Boston ReGen Therapy embraces the latest in advanced technologies to help men restore erectile function without the use of drugs or the long-term reliance on drugs.  Boston Medical Group utilizes treatment protocols which are personalized to the individual’s conditions and may combine regimens such as shockwave therapy called RejuvaPulse™ Therapy, BostonPRP Injections and Exosomes Therapy. Thanks to a vast amount continuing research and development, Boston Medical Group physicians have utilized the most efficacious treatment protocols and continue to be the market leader in the field Erectile Dysfunction.

 

Boston Medical Group’s Optimum Regenerative Solution

 

Boston Medical Group utilizes the latest in next generation revolutionary treatment options for Erectile Dysfunction while upholding to GMP guidelines, and the utmost standards or requirements regarding the utilization of FDA registered tissue procurement organizations for Exosomes Therapy. Boston Medical Group utilizes Stem-Cell Bioactive Factors secreted from the membranes of placental-derived MSCs (mesenchymal stem cells) which possess more than 200 growth factors as well as other immune factors which can render considerable therapeutic benefits.

 

 

References: 

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735142/#bib1
  2. https://www.ncbi.nlm.nih.gov/pubmed/18286209
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735142/#bib3
  4. https://www.ncbi.nlm.nih.gov/pubmed/17254699
  5. https://www.ncbi.nlm.nih.gov/pubmed/23456256?dopt=Abstract
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735142/#bib6
  7. https://www.ncbi.nlm.nih.gov/pubmed/23456256?dopt=Abstract
  8. https://www.ncbi.nlm.nih.gov/pubmed/16458737
  9. https://www.frontiersin.org/articles/10.3389/fphys.2016.00024/full
  10. https://www.mdpi.com/1422-0067/15/3/4142
  11. https://www.sciencedirect.com/science/article/pii/S2050052119300964#bib23
  12. https://www.sciencedirect.com/science/article/pii/S2050052119300964#bib24
  13. https://www.sciencedirect.com/science/article/pii/S2050052119300964#bib28
  14. https://www.sciencedirect.com/science/article/pii/S2050052119300964#bib29
  15. https://www.sciencedirect.com/science/article/pii/S2050052119300964#bib30
  16. https://www.sciencedirect.com/science/article/pii/S2050052119300964#bib31
  17. https://linkinghub.elsevier.com/retrieve/pii/S1743609517313401
  18. https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/stem.2445
  19. https://onlinelibrary.wiley.com/doi/abs/10.1111/and.12871
  20. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735142/#bib95
  21. https://www.sciencedirect.com/science/article/pii/S2050052119300964

 

This Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

 

An Exercise Routine Each Day Keeps Erectile Dysfunction Away?

by

While some men require multi-layered treatment to help in their battle with erectile dysfunction, others can get marked results by improving the way they take care of themselves.

Even if you do need a physician’s help, making changes in the way you live can multiply the benefits you get from treatment.

Try to exercise regularly. The research on the best methods of exercise call for doing it five days a week. Start at just a few minutes a day, if you’ve been inactive. As you get into the routine, and as you become more fit, work up to 30 minutes. If you can’t do five days a week, try to work out as much as you can.

Stick with it. The longer you keep exercise as part of your routine, the easier it is to keep the habit.

You can ask your doctor for help in finding a physical therapist, if you’re unsure about how to start exercising. With professional help, you can get a safe, solid start.

Try scheduling exercise into your day, and look for classes that you’ll have fun in and look forward to. If it’s less of a chore, you are more likely to keep it as part of your long-term lifestyle change.

When you begin to see results—especially the benefits exercise can bring to your sexual function—you may never want to stop!  Boston Medical Group encourages finding treatments of all kinds.

More on general Health and Wellness

For Men, Regular Doctor Visits are Extremely Important

by

Many men feel like their wives push them to go to the doctor’s office and according to a federal report, it’s for good reason. The report suggested that men are far less likely than women to keep regular checkup appointments. The importance of seeing your doctor regularly becomes more and more important with age, however, young men are also at risk for things like prostate cancer. Do not try to ‘play doctor’ to avoid the issue.

In comparison to women, men:

  • Drink more alcohol
  • Smoke more
  • Are more likely to skip regular visits to the doctor
  • Put off routine checkups and disregard symptoms of a health problem
  • Participate in reckless, risky, and dangerous activities

It is no wonder our wives push us. There is a bit of good news, however. Many diseases and health conditions that men face can be prevented or treated if they are found early enough. To start taking better care of your health, eliminate those risk factors that contribute to an unhealthy lifestyle. Talk to your doctor about diseases that run in your family such as heart disease, cancer, and sexual dysfunction. Some risk factors are genetic and others are in your control.

Sexual dysfunctions are often precursors to more serious medical conditions, so early diagnosis will pay off in the long run.

Exercise Discretion When Talking With Your Partner

by

The folks from Boston Medical Group know that when you have Erectile Dysfunction and you are in an existing relationship, things can get very awkward and uncomfortable for you.

This is where you have to exercise some discretion, and some wisdom, when it comes to speaking with your partner about the problem you are having.

It is extremely important that you are open and honest with your partner. There is nothing gained by being evasive or deceptive. It is also the best policy to get things out into the open, so that the problem can be addressed as a joint effort between partners in a committed relationship.

It is also counter-productive to assign blame; if you have the condition of Erectile Dysfunction, you may be feeling a certain level of inadequacy, and that is perfectly normal. It is also perfectly normal, as a defense mechanism, to look for someone to blame.  Sometimes you may even need to seek outside help on how to address the situation.

Those possibilities become even greater if you are suffering from Psychogenic Erectile Dysfunction, where you may have difficulties achieving erection with your wife or partner, but perhaps not otherwise. In these cases, there may be a strong tendency to point to the partner as the source of the problem, when it may in fact be caused by tension about the relationship that comes only from your end.

The most important thing is to come forward and seek treatment. Contact Boston Medical Group at 1-800-337-7555 and start attacking the problem. There are many offices located throughout the United States to serve you.